Strahl Lab WebsiteThe research in our group focuses on bacterial cell envelopes. Using a combination of cell biology, high-end fluorescence microscopy, genetics, and biochemistry, we study function, biosynthesis and internal organisation of bacterial cell wall and cell membranes using a repertoire of model organisms. This research also extends to studying protein lipid-interactions and how membrane association is used to establish higher-level internal organisation within bacterial cells. The fundamental research in our group is accompanied by more applied research lines aiming to understand the complex mode of action of cell envelope-targeting antimicrobials and toxins, why certain cellular targets are less vulnerable to rapid development of antibiotic resistance, and to discover new ones. |
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Bacterial membrane biology
We study the physico-chemical properties of bacterial membranes and the role of membrane-associated proteins in modulating membrane function. This includes research on IM30 proteins in safeguarding membrane integrity.
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Cell envelope-targeting antibiotics
We investigate the cellular consequences of cell wall and membrane -targeting antibiotics and antimicrobial peptides with focus on cell lysis, and lysis-independent killing processes.
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Bacterial cell wall biology
We study bacterial cell wall synthesis, and the role of bacterial actin homolog MreB in lipid domain formation and autolysis.
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